Quinuclidines as selective agonists for alpha-7 nicotinic acetylcholine receptors.
نویسندگان
چکیده
The alpha7 subtype of the neuronal nicotinic acetylcholine receptors (nAChRs) was targeted for the design of selective agonists deriving from the quinuclidine scaffold. Arylidene groups at the 3-position and N-methyl quinuclidine were found to be selective agonists with EC(50)s of 1.5 and 40 microM, respectively.
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ورودعنوان ژورنال:
- Bioorganic & medicinal chemistry letters
دوره 17 6 شماره
صفحات -
تاریخ انتشار 2007